Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration
2018; Elsevier BV; Volume: 179; Linguagem: Inglês
10.1016/j.biomaterials.2018.06.039
ISSN1878-5905
AutoresXuzhu Wang, Jundong Shao, Mustafa Abd El Raouf, Hanhan Xie, Hao Huang, Huaiyu Wang, Paul K. Chu, Xue‐Feng Yu, Yang Yang, Ahmed Abdelaal, Nefissa Helmy Mekkawy, Richard J. Miron, Yufeng Zhang,
Tópico(s)Bone health and treatments
ResumoA near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl2 and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl2/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr2+ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl2/PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr2+ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.
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