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667 Profile of Candidates to Penile Prosthesis Implantation for ED; Pooled Analysis from Two Prospective Population-based Registry

2018; Elsevier BV; Volume: 15; Issue: Supplement_3 Linguagem: Inglês

10.1016/j.jsxm.2018.04.575

1743-6109

Paolo Capogrosso, Edoardo Pescatori, K. Jani, E. Caraceni, Edward Karpman, A. Palmiéri, William O. Brant, Andrea Salonia, Mauro Silvani, Antonio Vitarelli, Diego Pozza, Stefano Fiordelise, Boselli Carlo, F. Deho', Gérard Henry,

Sexuality, Behavior, and Technology

We compared baseline characteristics data of patients submitted to penile prosthesis implantation (PPI), from two prospective multicenter population-based registries on penile prostheses surgery. Data were collected from the Italian multi-institutional, monitored and internal review board (IRB) approved registry on PPI (INSIST-ED) including data from 33 institutions. Similarly, data from the IRB-approved Prospective Registry of Outcomes with Penile Prosthesis for Erectile Restoration (PROPPER), a large prospective dataset including data from 13 North American sites, were also collected. Both registries include data on patient’s baseline characteristics, ED etiology, surgical and peri-operative management strategies. As a primary outcome of this study, a pooled data analysis was conducted to assess differences in patient’s baseline characteristics between the two registries; continuous and categorical variables were analyzed with the Wilcoxon Rank Sum test and the Pearson’s Chi square test, accordingly. Data from 405(23.2%) patients from the INSIST-ED registry and 1340(76.8%) from the PROPPER study were analyzed. Patients in the PROPPER study were older compared to those included in the Italian registry [median (IQR): 65 (58- 70)vrs 62 (56-67); p<0.001]. Overall, radical prostatectomy (RP) was the most common ED etiology, reported in 486(27.9%) cases; however, the distribution of ED etiologies was significantly different between the two registries: cardiovascular disease [251(18.7%)] and diabetes [282 (21%)] were more frequently reported as a main cause of ED in the PROPPER study compared to the INSIST-ED [31(7.7%) and 43(10.6%), respectively; p<0.001]. Conversely, more patients were submitted to PPI for ED secondary to Peyronie’s disease [68(16.8%) vs 123(9.2%); p<0.001] and pelvic surgery other than RP [40(9.9%) vs 21 (1.6%); p<0.001] in the INSIST-ED registry compared to the PROPPER. Moreover, although being infrequent in both studies, more patients were submitted to PPI after radiation therapy in the PROPPER study compared to the INSIST-ED [36 (2.7%) vs 1(0.2%);p=0.003].