Neurite Guidance on Laser-Scribed Reduced Graphene Oxide
2018; American Chemical Society; Volume: 18; Issue: 12 Linguagem: Inglês
10.1021/acs.nanolett.8b01651
ISSN1530-6992
AutoresSang Hwa Lee, Han Byeol Lee, Yoonyoung Kim, Jae Ryeol Jeong, Min Hyung Lee, Kyungtae Kang,
Tópico(s)Graphene research and applications
ResumoThis paper describes a one-step, chemical-free method to generate micropatterned in vitro neuronal networks on chemically unmodified reduced graphene oxide. The suggested method relies on infrared-based photothermal reduction of graphene oxide, which concurrently leads to the formation of submicrometer-scale surface roughness that promotes neuronal adhesion and guides neurite outgrowth. A commercially available laser source (LightScribe DVD drive) controlled by a computer software can be used to reduce graphene oxide (GO), and its repetitive scribing to a GO film brings about gradual increase and decrease in electrical conductivity and neurite guiding ability of the scribed regions, respectively. Our results also indicate that the observed adhesion-promoting and neurite guiding effect originate from the contrast in surface nanotopography, but not that in conductivity. This method is readily applicable to diverse graphene-based biomedical devices.
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