Acidic intracellular Ca2+ stores and caveolae in Ca2+ signaling and diabetes
2014; Elsevier BV; Volume: 56; Issue: 5 Linguagem: Inglês
10.1016/j.ceca.2014.08.005
ISSN1532-1991
AutoresAgustı́n Guerrero-Hernández, Martin Leonardo Gallegos-Gomez, Víctor Hugo Sánchez-Vázquez, María Cristina López-Méndez,
Tópico(s)Cellular transport and secretion
ResumoAcidic Ca(2+) stores, particularly lysosomes, are newly discovered players in the well-orchestrated arena of Ca(2+) signaling and we are at the verge of understanding how lysosomes accumulate Ca(2+) and how they release it in response to different chemical, such as NAADP, and physical signals. Additionally, it is now clear that lysosomes play a key role in autophagy, a process that allows cells to recycle components or to eliminate damaged structures to ensure cellular well-being. Moreover, lysosomes are being unraveled as hubs that coordinate both anabolism via insulin signaling and catabolism via AMPK. These acidic vesicles have close contact with the ER and there is a bidirectional movement of information between these two organelles that exquisitely regulates cell survival. Lysosomes also connect with plasma membrane where caveolae are located as specialized regions involved in Ca(2+) and insulin signaling. Alterations of all these signaling pathways are at the core of insulin resistance and diabetes.
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