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Common traits between the beige fat-inducing stimuli

2018; Elsevier BV; Volume: 55; Linguagem: Inglês

10.1016/j.ceb.2018.05.011

1879-0410

Ozren Stojanović, Silas Kieser, Mirko Trajkovski,

Exercise and Physiological Responses

Adipose tissues play an essential role in regulating the metabolic homeostasis and can be found in almost all parts of the body. Excessive adiposity leads to obesity and can contribute to metabolic and other disorders. Adipocytes show remarkable plasticity in their function, which can be pushed toward energy storage, or energy expenditure — a `browning' of fat. Browning is controlled by the cellular milieu of the adipose tissue, with sympathetic innervation and by immune responses as key integrators of the signals that promote browning. Here, we describe the latest contributions to our understanding of how different metabolic stimuli can shape the adipocyte function. We especially focus on the role of the gut microbiota and the negative energy balance in regulating the browning.