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Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity

2018; American Society for Microbiology; Volume: 62; Issue: 9 Linguagem: Inglês

10.1128/aac.01019-18

1098-6596

Seong Won Choi, Yuexi Gu, Ryan Peters, Padmini Salgame, Jerrold J. Ellner, Graham S. Timmins, Vojo Deretić,

Phenothiazines and Benzothiazines Synthesis and Activities

Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs. At clinically relevant doses, ambroxol induced autophagy in vitro and in vivo and promoted mycobacterial killing in macrophages. Ambroxol also potentiated rifampin activity in a murine tuberculosis model.