Artigo Acesso aberto Revisado por pares

LRRK2 activation in idiopathic Parkinson’s disease

2018; American Association for the Advancement of Science; Volume: 10; Issue: 451 Linguagem: Inglês

10.1126/scitranslmed.aar5429

ISSN

1946-6242

Autores

Roberto Di Maio, Eric K. Hoffman, Emily M. Rocha, Matthew T. Keeney, Laurie H. Sanders, Briana R. De Miranda, Alevtina Zharikov, Amber D. Van Laar, Antonia F. Stepan, Thomas A. Lanz, Julia Kofler, Edward A. Burton, Dario R. Alessi, Teresa G. Hastings, J. Timothy Greenamyre,

Tópico(s)

Botulinum Toxin and Related Neurological Disorders

Resumo

Wild-type LRRK2 is activated in nigrostriatal dopamine neurons in idiopathic Parkinson’s disease and plays a pathogenic role in this neurodegenerative disorder.

Referência(s)