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Functionalization of graphene family nanomaterials for application in cancer therapy

2018; Elsevier BV; Volume: 171; Linguagem: Inglês

10.1016/j.colsurfb.2018.07.030

1873-4367

Duarte de Melo‐Diogo, Rita Lima‐Sousa, Cátia G. Alves, Elisabete C. Costa, P. Louro, Ilídio J. Correia,

Carbon and Quantum Dots Applications

Graphene family nanomaterials' (GFN) ability to interact with near-infrared light has propelled their application in cancer photothermal therapy. Furthermore, the graphitic lattice of GFN can adsorb different types of molecules, which has motivated their use in cancer drug delivery. However, the direct application of GFN in cancer therapy is severely hindered by their poor colloidal stability, sub-optimal safety, inefficient tumor uptake and non-selectivity towards cancer cells. To overcome these limitations, GFN have been functionalized with different types of materials. This review is focused on the different functionalizations used in the design of GFN aimed for application in cancer therapy, disclosing their role on surpassing the critical issues related to GFN-based therapies.