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Study of the mechanism of environmentally friendly translucent balsa-modified lysozyme dressing for facilitating wound healing

2018; Dove Medical Press; Volume: Volume 13; Linguagem: Inglês

10.2147/ijn.s165075

1178-2013

Daijun Zhou, Tao Yang, Wei Qian, Malcolm Xing, Gaoxing Luo,

Silk-based biomaterials and applications

This study aimed to prepare an eco-friendly dressing using a balsa-derived membrane with lysozymes designed for antibacterial purposes.The groups included controls, balsa (group A), translucent balsa (group B), translucent balsa-lysozymes (group C), and translucent balsa-modified lysozymes (group D). Physical and chemical methods were used to characterize the materials, and the function of the materials was evaluated by in vivo and in vitro experiments.Antibacterial activity against Escherichia coli and Staphylococcus aureus was ordered D > C > B ≈ A (P C > B ≈ A > control (P C > B ≈ A > control (P C > B ≈ A > control (P 0.05). The order of expression of axin was D < C < B ≈ A < control (P C > B ≈ A > control (P<0.05).This translucent balsa-modified lysozyme dressing is characterized by strong antibacterial properties, stable and persistent release, no cytotoxicity, and capacity to promote antibacterial ability and epithelial growth, as well as cell proliferation and migration.