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BIBTEX RIS

New insights into the mechanism of antifungal action of 8-hydroxyquinolines

2018; Elsevier BV; Volume: 27; Issue: 1 Linguagem: Inglês

10.1016/j.jsps.2018.07.017

ISSN

2213-7475

Autores

Bruna Pippi, William Lopes, Paula Reginatto, Fernanda Émili Klein Silva, Angélica Rocha Joaquim, Ricardo José Alves, Gustavo P. Silveira, Marilene Henning Vainstein, Saulo Fernandes de Andrade, Alexandre Meneghello Fuentefría,

Tópico(s)

Bioactive Compounds and Antitumor Agents

Resumo

The 8-hydroxyquinoline core is a privileged scaffold for drug design explored to afford novel derivatives endowed with biological activity. Our research aimed at clarifying the antifungal mechanism of action of clioquinol, 8-hydroxy-5-quinolinesulfonic acid, and 8-hydroxy-7-iodo-5-quinolinesulfonic acid (three 8-hydroxyquinoline derivatives). The antifungal mode of action of these derivatives on

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