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Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by resistance training

2018; Elsevier BV; Volume: 111; Linguagem: Inglês

10.1016/j.exger.2018.07.014

1873-6815

Carlos Henrique de Lemos Muller, Anderson Rech, Cíntia Ehlers Botton, Helena Trevisan Schroeder, Patrícia Martins Bock, Juliano Boufleur Farinha, Pedro López, Cinthia Maria Schöler, Gisele Bettú Grigolo, J. C. Coelho, Lucas Stahlhöfer Kowalewski, Maria Inês Lavina Rodrigues, Marcela Alves de Azevedo, André Quincozes‐Santos, Josianne Rodrigues‐Krause, Álvaro Reischak-Oliveira, Ronei Silveira Pinto, Giuseppe De Vito, Paulo Ivo Homem de Bittencourt, Maurício Krause,

Heat shock proteins research

Recent evidence suggests that the anti-inflammatory heat shock response (HSR) is reduced in aging and diabetes. In this study we compared HSR between healthy middle-aged adults, healthy elderly and type 2 diabetic (T2DM) elderly, and tested whether resistance training (RT) could improve the HSR in T2DM group. Thirty sedentary participants volunteered for this study. HSR (assessed as the capacity to export HSP72 during heat stress) was measured in the blood and compared between the groups. HSR was similar between healthy middle-aged and healthy elderly volunteers, but diminished in elderly T2DM (p < 0.001). Hence, T2DM subjects (n = 12) were submitted to a 12-week RT program, because exercise is a physiological HSR inducer. HSR, cytokines, metabolic parameters and visceral adipose tissue (VAT) were measured before and after the RT. Remarkably, VAT was negatively correlated with HSR (r = − 0.49, p < 0.01) while RT improved the HSR and reduced inflammation [TNF-α: from 51.5 ± 9 to 40.7 ± 4 pg/mL and TNF-α/IL-10 ratio: from 1.55 ± 0.3 to 1.16 ± 0.2 (p < 0.001)], without affecting other parameters. All together, these findings confirm the hypothesis that the anti-inflammatory HSR is depressed in elderly diabetic people, but can be partially restored by RT.