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Ascaris lumbricoides infection induces both, reduction and increase of asthma symptoms in a rural community

2018; Elsevier BV; Volume: 187; Linguagem: Inglês

10.1016/j.actatropica.2018.07.016

1873-6254

Josefina Zakzuk, Stephanie Casadiego, Ana Carolina Mercado, Nelson Alvis‐Guzmán, Luis Caraballo,

Parasite Biology and Host Interactions

Several studies, in different populations and environments, have shown that severe and light helminthiases diminish and increase allergy symptoms, respectively. However, data on the simultaneous presence of these contrary effects in a single community is lacking. In a rural community from Colombia, effects of helminthiases on allergy were evaluated. In the study population, age and gender-adjusted prevalence of asthma and rhinitis symptoms in the last year was 14.6% and 34.1%, respectively (N = 739). By stool exam, ascariasis and trichuriasis were 62.5% and 35.7%, respectively. Significant odds ratio (OR) for asthma presentation were Ascaris sensitization, by specific-IgE (aOR: 2.69, 95%CI: 1.21–5.98) or skin prick test (OR: 3.59, 95%CI: 1.55–8.29). Moderate/severe ascariasis was protective from asthma (aOR: 0.34, 95%CI: 0.12–0.99) and moderate/severe trichuriasis from rhinitis (aOR: 0.35, 95%CI: 0.15–0.80). In conclusion, in a rural tropical village, ascariasis exerts risk and protective effects on asthma symptoms, an influence associated with the severity of the infection.