Multivalent Meningococcal Conjugate Vaccines: Chemical Conjugation Strategies Used for the Preparation of Vaccines Licensed or in Clinical Trials
2018; American Chemical Society; Linguagem: Inglês
10.1021/bk-2018-1290.ch006
ISSN1947-5918
Autores Tópico(s)Peptidase Inhibition and Analysis
ResumoSeveral multi-valent carbohydrate-based vaccines have been licensed or are currently in clinical development, so far, to prevent bacterial infection caused by several serogroup of Neisseria meningitidis. In this chapter, the conjugation strategies, including the chemical structures and functional groups involved in the covalent coupling of polysaccharides to carrier proteins for the preparation of tetravalent meningococcal serogroup A, C, W, Y glycoconjugates vaccines, have been described in depth.
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