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The 2018 biomembrane curvature and remodeling roadmap

2018; Institute of Physics; Volume: 51; Issue: 34 Linguagem: Inglês

10.1088/1361-6463/aacb98

1361-6463

Patricia Bassereau, Rui Jin, Tobias Baumgart, Markus Deserno, Rumiana Dimova, Vadim A. Frolov, Pavel V. Bashkirov, Helmut Grubmüller, Reinhard Jahn, Herre Jelger Risselada, Ludger Johannes, Michael M. Kozlov, Reinhard Lipowsky, Thomas J. Pucadyil, Wade F. Zeno, Jeanne C. Stachowiak, Dimitrios Stamou, Artù Breuer, Line Lauritsen, Camille Simon, Cécile Sykes, Gregory A. Voth, Thomas R. Weikl,

Cellular transport and secretion

The importance of curvature as a structural feature of biological membranes has been recognized for many years and has fascinated scientists from a wide range of different backgrounds. On the one hand, changes in membrane morphology are involved in a plethora of phenomena involving the plasma membrane of eukaryotic cells, including endo- and exocytosis, phagocytosis and filopodia formation. On the other hand, a multitude of intracellular processes at the level of organelles rely on generation, modulation, and maintenance of membrane curvature to maintain the organelle shape and functionality. The contribution of biophysicists and biologists is essential for shedding light on the mechanistic understanding and quantification of these processes.