Interleukin-1β has atheroprotective effects in advanced atherosclerotic lesions of mice
2018; Nature Portfolio; Volume: 24; Issue: 9 Linguagem: Inglês
10.1038/s41591-018-0124-5
ISSN1546-170X
AutoresDelphine Gomez, Richard A. Baylis, Brittany G. Durgin, Alexandra Newman, Gabriel F. Alencar, Sidney Mahan, Cynthia St. Hilaire, Werner Müller, Ari Waisman, Sheila Francis, Emmanuel Pinteaux, Gwendalyn J. Randolph, Hermann Gram, Gary K. Owens,
Tópico(s)Adipokines, Inflammation, and Metabolic Diseases
ResumoDespite decades of research, our understanding of the processes controlling late-stage atherosclerotic plaque stability remains poor. A prevailing hypothesis is that reducing inflammation may improve advanced plaque stability, as recently tested in the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial, in which post-myocardial infarction subjects were treated with an IL-1β antibody. Here, we performed intervention studies in which smooth muscle cell (SMC) lineage-tracing Apoe
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