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Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines

2018; Multidisciplinary Digital Publishing Institute; Volume: 23; Issue: 8 Linguagem: Inglês

10.3390/molecules23082018

1433-1373

Tatiana Takahasi Komoto, Tayná Minervina Bernardes, Thaís Balthazar Mesquita, Luis Felipe Buso Bortolotto, Gabriel Silva, Tamires A. Bitencourt, Seung Joon Baek, Mozart Marins, Ana Lúcia Fachin,

Bioactive Compounds and Antitumor Agents

In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins.