Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Cytokine Levels and Human Herpesviruses in Saliva from Clinical Periodontal Healthy Subjects with Peri-Implantitis: A Case-Control Study

2018; Hindawi Publishing Corporation; Volume: 2018; Linguagem: Inglês

10.1155/2018/6020625

1466-1861

Jaime S. Marques Filho, Jorge Gobara, Gustavo Vargas da Silva Salomão, Laura Masami Sumita, Jamil Awad Shibli, Renato G. Viana, Humberto Osvaldo Schwartz‐Filho, Cláudio Mendes Pannuti, Paulo Henrique Braz‐Silva, Débora Pallos,

Dental Implant Techniques and Outcomes

This study evaluated the presence of cytokines (IL-1 β , IL-2, IL-4, IL-6, MCP-1, MIP-1 α , MIP-1 β , and TNF- α ) and human herpesvirus (HSV1, HSV2, EBV, CMV, VZV, HHV6, HHV7, and HHV8) in saliva samples taken from subjects with and without peri-implantitis. Forty-two periodontally healthy subjects were divided according to peri-implant condition: healthy and peri-implantitis groups. The clinical parameters as probing depth, clinical attachment level, plaque index, gingival bleeding, bleeding on probing, and suppuration were evaluated. For cytokine detection, multiplex analysis was performed, and PCR assay was used to identify herpesviruses. No significant differences were found in cytokine levels between groups ( p > 0.05 ). The presence of herpesvirus was 1.97-fold higher in patients with peri-implantitis (odds ratio, CI 0.52–7.49). The association of the presence or absence of herpesvirus with the salivary markers was statistically significant for MIP-1 β ( p = 0.0087 ) and TNF- α ( p = 0.0437 ) only in the peri-implantitis group. The presence of herpesviruses in patients with peri-implantitis suggests the development of a proinflammatory environment, which is characterized by increased expression of MIP-1 β and TNF- α in saliva.