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Synthesis of β-alkoxy- N -protected phenethylamines via one-pot copper-catalyzed aziridination and ring opening

2018; Royal Society of Chemistry; Volume: 8; Issue: 49 Linguagem: Inglês

10.1039/c8ra03815e

2046-2069

Jorge Saavedra‐Olavarría, Matías Madrid‐Rojas, Iriux Almodóvar, Patricio Hermosilla‐Ibáñez, Edwin G. Pérez,

Sulfur-Based Synthesis Techniques

A regioselective, copper-catalyzed, one-pot aminoalkoxylation of styrenes using primary and secondary alcohols and three different iminoiodanes as alkoxy and nitrogen sources respectively, is reported. The β-alkoxy-N-protected phenethylamines obtained were used to synthesise β-alkoxy-N-benzylphenethylamines which are interesting new compounds that could act as possible neuronal ligands.