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Iron-Requiring Enzymes in the Spotlight of Oxygen

2018; Elsevier BV; Volume: 23; Issue: 10 Linguagem: Inglês

10.1016/j.tplants.2018.07.005

1878-4372

Gianpiero Vigani, Irene Murgia,

Cassava research and cyanide

Iron is an essential cofactor for a variety of redox reactions in plant metabolism and Fe-requiring enzymes (FeRE) catalyse reactions that also involve oxygen, as a reagent/product of the reaction itself or as an entry/end point of a metabolic pathway. The large amount of data collected by omics technologies revealed that the complex responses of a plant facing iron deficiency involve several metabolic pathways. Although FeRE are differentially affected in Fe-deficient plants, a clear overview of their involvement during Fe deficiency responses is still lacking. Fe-oxygen relationship might represent a new point of view to revisit metabolic reprogramming occurring under Fe deficiency. Iron (Fe) is a cofactor required for a variety of essential redox reactions in plant metabolism. Thus, plants have developed a complex network of interacting pathways to withstand Fe deficiency, including metabolic reprogramming. This opinion aims at revisiting such reprogramming by focusing on: (i) the functional relationships of Fe-requiring enzymes (FeREs) with respect to oxygen; and (ii) the progression of FeREs engagement, occurring under Fe deficiency stress. In particular, we considered such progression of FeREs engagement as strain responses of increasing severity during the stress phases of alarm, resistance, and exhaustion. This approach can contribute to reconcile the variety of experimental results obtained so far from different plant species and/or different Fe supplies. Iron (Fe) is a cofactor required for a variety of essential redox reactions in plant metabolism. Thus, plants have developed a complex network of interacting pathways to withstand Fe deficiency, including metabolic reprogramming. This opinion aims at revisiting such reprogramming by focusing on: (i) the functional relationships of Fe-requiring enzymes (FeREs) with respect to oxygen; and (ii) the progression of FeREs engagement, occurring under Fe deficiency stress. In particular, we considered such progression of FeREs engagement as strain responses of increasing severity during the stress phases of alarm, resistance, and exhaustion. This approach can contribute to reconcile the variety of experimental results obtained so far from different plant species and/or different Fe supplies.