Predictors for High Microsatellite Instability in Patients with Colorectal Cancer Fulfilling the Revised Bethesda Guidelines
2018; International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts; Volume: 38; Issue: 8 Linguagem: Inglês
10.21873/anticanres.12800
ISSN1791-7530
AutoresK Arakawa, Keisuke Hata, Kazushige Kawai, Toshiaki Tanaka, Takeshi Nishikawa, Kazuhito Sasaki, Yasutaka Shuno, Manabu Kaneko, Masaya Hiyoshi, Shigenobu Emoto, Koji Murono, Hiroaki Nozawa,
Tópico(s)Genetic factors in colorectal cancer
ResumoThe revised Bethesda guidelines (rBG) are generally used for screening of Lynch syndrome, and few researchers have investigated the associations between microsatellite instability (MSI) status and each item of the rBG.This retrospective study included patients with colorectal cancer who were classified into those fulfilling the rBG (Bethesda group) and those not (control group). The breakdown of each item in the rBG and predictors of high MSI (MSI-H) were determined in the Bethesda group.Of 809 consecutive patients, 161 (19.9%) were found to fulfil the rBG criteria. As a predictor of MSI-H, items 2 or 5 of the rBG showed a sensitivity of 93.3%. Item 5 and right-sided tumour location were independent predictors of MSI-H in patients fulfilling the rBG (odds ratio(OR)=4.49 and 25.1; p=0.0260 and <0.0001, respectively).Item 5 of the rBG and right-sided tumour location are significant predictors of MSI-H.
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