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BIBTEX RIS

Targeting neurodegeneration to prevent post-traumatic epilepsy

2018; Elsevier BV; Volume: 123; Linguagem: Inglês

10.1016/j.nbd.2018.08.006

ISSN

1095-953X

Autores

Idrish Ali, Juliana Silva, Shijie Liu, Sandy R. Shultz, Patrick Kwan, Nigel C. Jones, Terence J. O’Brien,

Tópico(s)

Epilepsy research and treatment

Resumo

In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.

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