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Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study

2018; Elsevier BV; Volume: 3; Issue: 6 Linguagem: Inglês

10.1016/j.ekir.2018.07.021

2468-0249

David T. Selewski, Josephine M. Ambruzs, Gerald B. Appel, Andrew S. Bomback, Raed Bou Matar, Yi Cai, Daniel C. Cattran, Aftab S. Chishti, Vivette D. D’Agati, Cynthia D’Alessandri-Silva, Rasheed Gbadegesin, Jonathan Hogan, Sandra Iragorri, J. Charles Jennette, Bruce A. Julian, Myda Khalid, Richard A. Lafayette, Helen Liapis, Francesca Lugani, Sarah Mansfield, Sherene Mason, Patrick H. Nachman, Cynthia C. Nast, Carla Nester, Damien Noone, Jan Novák, Michelle M. O’Shaughnessy, Heather N. Reich, Michelle N. Rheault, Dana V. Rizk, Manish K. Saha, Neil Sanghani, C. John Sperati, Rajasree Sreedharan, Tarak Srivastava, Agnieszka Swiatecka‐Urban, Katherine Twombley, Tetyana L. Vasylyeva, Donald J. Weaver, Hong Yin, Jarcy Zee, Ronald J. Falk, Ali G. Gharavi, Brenda W. Gillespie, Debbie S. Gipson, Larry A. Greenbaum, Lawrence B. Holzman, Matthias Kretzler, Bruce Robinson, William E. Smoyer, Michael F. Flessner, Lisa M. Guay‐Woodford, Krzysztof Kiryluk, Ali G. Gharavi, Wooin Ahn, Gerald B. Appel, Rupali S. Avasare, Revekka Babayev, Ibrahim Batal, Andrew S. Bomback, Eric J. Brown, Eric S. Campenot, Pietro A. Canetta, Brenda Chan, Vivette D. D’Agati, Hilda Fernández, Bartosz Foroncewicz, Gian Marco Ghiggeri, William H. Hines, Namrata G. Jain, Krzysztof Kiryluk, Fangming Lin, Francesca Lugani, Maddalena Marasà, Glen S. Markowitz, Sumit Mohan, Krzysztof Mucha, Thomas L. Nickolas, Jai Radhakrishnan, Maya K. Rao, Renu Regunathan-Shenk, Simone Sanna‐Cherchi, Dominick Santoriello, Michael B. Stokes, Natalie Yu, Anthony M. Valeri, Ronald Zviti, Larry A. Greenbaum, William E. Smoyer, Amira Al‐Uzri, Isa Ashoor, Diego Avilés, Rossana Baracco, John Barcia, Sharon Bartosh, Craig W. Belsha, Michael Braun, Aftab S. Chishti, Donna Claes, Carl H. Cramer, Keefe Davis, Elif Erkan, Daniel I. Feig, Michael Freundlich, Melisha Hanna, Guillermo Hidalgo, Amrish Jain, Myda Khalid, Mahmoud Kallash, Jerome C. Lane, John D. Mahan, Nisha Mathews, Carla Nester, Cynthia G. Pan, Hiren Patel, Adelaide Revell, Rajasree Sreedharan, Julia Steinke, Scott E. Wenderfer, Craig S. Wong, Ronald J. Falk, W. James Cook, Vimal K. Derebail, Agnes B. Fogo, Adil Gasim, Todd W.B. Gehr, Raymond C. Harris, Jason M. Kidd, Louis‐Philippe Laurin, Will Pendergraft, Vincent Pichette, Thomas Brian Powell, Matthew B. Renfrow, Virginie Royal, Lawrence B. Holzman, Sharon G. Adler, Charles E. Alpers, Raed Bou Matar, Elizabeth Brown, Daniel C. Cattran, Michael Choi, Katherine M. Dell, Ram Dukkipati, Fernando C. Fervenza, Alessia Fornoni, Crystal A. Gadegbeku, Patrick Gipson, Leah Hasely, Sangeeta Hingorani, Michelle Hladunewich, Jonathan Hogan, J. Ashley Jefferson, Kenar D. Jhaveri, Duncan B. Johnstone, Frederick J. Kaskel, Amy Kogan, Jeffrey B. Kopp, Kevin V. Lemley, Laura Malaga- Dieguez, Kevin Meyers, Alicia M. Neu, Michelle M. O’Shaughnessy, John F. O’Toole, Rulan S. Parekh, Heather N. Reich, Kimberly Reidy, Helbert Rondon‐Berrios, Kamalanathan K. Sambandam, John R. Sedor, David T. Selewski, Christine B. Sethna, Jeffrey R. Schelling, C. John Sperati, Agnieszka Swiatecka‐Urban, Howard Trachtman, Katherine R. Tuttle, Joseph Weisstuch, Olga Zhdanova, Brenda W. Gillespie, Debbie S. Gipson, Matthias Kretzler, Bruce Robinson, Laura Barisoni, Sarah Mansfield, Laura Mariani, Cynthia C. Nast, Matthew Wladkowski, Jarcy Zee, Lisa M. Guay‐Woodford,

Platelet Disorders and Treatments

The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This study describes the clinical characteristics and treatment patterns in the IgA cohort, including comparisons between IgAN versus IgAV and adult versus pediatric patients.Patients with a diagnostic kidney biopsy within 5 years of screening were eligible to join CureGN. This is a descriptive analysis of clinical and treatment data collected at the time of enrollment.A total of 667 patients (506 IgAN, 161 IgAV) constitute the IgAN/IgAV cohort (382 adults, 285 children). At biopsy, those with IgAV were younger (13.0 years vs. 29.6 years, P < 0.001), more frequently white (89.7% vs. 78.9%, P = 0.003), had a higher estimated glomerular filtration rate (103.5 vs. 70.6 ml/min per 1.73 m2, P < 0.001), and lower serum albumin (3.4 vs. 3.8 g/dl, P < 0.001) than those with IgAN. Adult and pediatric individuals with IgAV were more likely than those with IgAN to have been treated with immunosuppressive therapy at or prior to enrollment (79.5% vs. 54.0%, P < 0.001).This report highlights clinical differences between IgAV and IgAN and between children and adults with these diagnoses. We identified differences in treatment with immunosuppressive therapies by disease type. This description of baseline characteristics will serve as a foundation for future CureGN studies.