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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

2018; American Association for the Advancement of Science; Volume: 10; Issue: 454 Linguagem: Inglês

10.1126/scitranslmed.aan1230

1946-6242

Thomas G. Bird, Miryam Müller, Luke Boulter, David F. Vincent, Rachel A. Ridgway, Elena Lopez-Guadamillas, Wei‐Yu Lu, Thomas Jamieson, Olivier Govaere, Andrew D. Campbell, Sofía Ferreira-González, Alicia M. Cole, Trevor Hay, Kenneth J. Simpson, William Clark, Ann Hedley, Mairi Clarke, Pauline Gentaz, Colin Nixon, S Bryce, Christos Kiourtis, Joep Sprangers, Robert J. B. Nibbs, Nico van Rooijen, Laurent Bartholin, Steven R. McGreal, Udayan Apte, Simon T. Barry, John P. Iredale, Alan R. Clarke, Manuel Serrano, Tania Roskams, Owen J. Sansom, Stuart J. Forbes,

Cancer Research and Treatments

Inhibiting acute injury–induced senescence mediated by TGFβ signaling in regenerative epithelium improves liver regeneration.