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Ciprofloxacin degradation by first-, second-, and third-generation manganese porphyrins

2018; Elsevier BV; Volume: 360; Linguagem: Inglês

10.1016/j.jhazmat.2018.08.036

1873-3336

Ana Luísa Almeida Lage, Alexandre Moreira Meireles, Aline Capelão Marciano, Juliana Martins Ribeiro, Elaine M. Souza–Fagundes, Dayse Carvalho da Silva Martins,

Antibiotics Pharmacokinetics and Efficacy

A range of hydrophobic first-, second-, and third-generation manganese porphyrins (MnPs) was investigated as cytochrome P450 models for degradation of the antibiotic ciprofloxacin (CIP). The experiments were carried out under mild conditions; oxidants such as iodosylbenzene (PhIO), H2O2, and meta-chloroperbenzoic acid were employed. The PhIO system yielded the best results: CIP degradation ranged between 56% and 76%. CIP degradation was not directly related to MnP generation. The second-generation MnP afforded the best result with the advantage that it required less preparation effort as compared to the third-generation MnP. Some new degradation products in MnP-mediated ciprofloxacin degradation were proposed, and the products of the reaction are not cytotoxic under the conditions evaluated.