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Genetic influence alters the brain synchronism in perception and timing

2018; BioMed Central; Volume: 25; Issue: 1 Linguagem: Inglês

10.1186/s12929-018-0463-z

1423-0127

Victor Marinho, Antônio Thomaz de Oliveira, Juliete Bandeira, Giovanny R. Pinto, Anderson José Baía Gomes, Valéria Morgiana Gualberto Duarte Moreira Lima, Francisco Magalhães, Kaline Rocha, Carla Ayres, Valécia Carvalho, Bruna Velasques, Pedro Ribeiro, Marco Orsini, Víctor Hugo Bastos, Daya S. Gupta, Silmar Teixeira,

Circadian rhythm and melatonin

Studies at the molecular level aim to integrate genetic and neurobiological data to provide an increasingly detailed understanding of phenotypes related to the ability in time perception. This study suggests that the polymorphisms genetic SLC6A4 5-HTTLPR, 5HTR2A T102C, DRD2/ANKK1-Taq1A, SLC6A3 3’-UTR VNTR, COMT Val158Met, CLOCK genes and GABRB2 A/C as modification factor at neurochemical levels associated with several neurofunctional aspects, modifying the circadian rhythm and built-in cognitive functions in the timing. We conducted a literature review with 102 studies that met inclusion criteria to synthesize findings on genetic polymorphisms and their influence on the timing. The findings suggest an association of genetic polymorphisms on behavioral aspects related in timing. However, order to confirm the paradigm of association in the timing as a function of the molecular level, still need to be addressed future research.