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Clinopodium nubigenum (Kunth) Kuntze essential oil: Chemical composition, antioxidant activity, and antimicrobial test against respiratory pathogens

2018; Academic Journals; Volume: 10; Issue: 9 Linguagem: Inglês

10.5897/jpp2017.0467

2141-2502

Fernando Noriega Paco, de los Angeles Mosquera Tatiana, Antonio Osorio Edison, Guerra Pablo, Fonseca Ferreira Andréa,

Psidium guajava Extracts and Applications

The essential oil of leaves and flowers of Clinopodium nubigenum (Kunth.) Kuntze (Lamiaceae) collected in the province of Pichincha-Ecuador was steam distilled and analyzed by gas chromatography mass spectrometry (GC/MS) to determine its chemical composition. The majority of the compounds identified were carvacrol acetate (42.1%), carvacrol (20.6%), pulegone (6.3%) and thymol (5.5%). Antioxidant activity was assessed by the assays of diphenylpicrylhydrazyl (DPPH) (IC50: 1.8 μl / ml), 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) (IC50: 0.3 μl / ml) and β-carotene (IC50: 0.031 μl / ml) compared to Thymus vulgaris and butylated hydroxyanisole (BHA) as referents. The specie also shows a promising medicinal potential exhibiting significant antibacterial activity at different concentrations against Staphylococcus aureus (2.5% v/v), Streptococcus pyogenes (0.6% v/v), Streptococcus pneumoniae (0.6% v/v) and Streptococcus mutans (0.6% v/v), suggesting an interesting natural alternative in the fight against bacteria that generate resistance to other antibiotics. Key words: Clinopodium nubigenum, gas chromatography mass spectrometry (GC/MS), 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS), diphenylpicrylhydrazyl (DPPH), antimicrobial test.