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Understanding the evolving phenotype of vascular complications in telomere biology disorders

2018; Springer Science+Business Media; Volume: 22; Issue: 1 Linguagem: Inglês

10.1007/s10456-018-9640-7

1573-7209

Cecilia Higgs, Yanick J. Crow, Denise M. Adams, Emmanuel Chang, Don Hayes, Utz Herbig, James N. Huang, Ryan Himes, Kunal Jajoo, F. Brad Johnson, Susan D. Reynolds, Yoshihiro Yonekawa, Mary Armanios, Farid Boulad, Courtney D. DiNardo, Carlo Dufour, Frederick D. Goldman, Shakila P. Khan, Christian P. Kratz, Kasiani C. Myers, Ganesh Raghu, Blanche P. Alter, Geraldine Aubert, Sonia Bhala, Edward W. Cowen, Yigal Dror, Mounif El‐Youssef, Bruce Friedman, Neelam Giri, Lisa Helms Guba, Payal P. Khincha, Tiffany Lin, Hilary Longhurst, Lisa J. McReynolds, Adam Nelson, Tim Olson, Anne Pariser, Rosario Perona, Ghadir Sasa, Kristen E. Schratz, Douglas A. Simonetto, Danielle Townsley, Michael F. Walsh, Kate Stevens, Suneet Agarwal, Alison A. Bertuch, Sharon A. Savage,

Tissue Engineering and Regenerative Medicine

Vascular complications such as bleeding due to gastrointestinal telangiectatic anomalies, pulmonary arteriovenous malformations, hepatopulmonary syndrome, and retinal vessel abnormalities are being reported in patients with telomere biology disorders (TBDs) more frequently than previously described. The international clinical care consortium of telomere-associated ailments and family support group Dyskeratosis Congenita Outreach, Inc. held a workshop on vascular abnormalities in the TBDs at the National Cancer Institute in October 2017. Clinicians and basic scientists reviewed current data on vascular complications, hypotheses for the underlying biology and developed new collaborations to address the etiology and clinical management of vascular complications in TBDs.