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X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice

2018; Elsevier BV; Volume: 129; Issue: 3 Linguagem: Inglês

10.1016/j.radonc.2018.08.016

1879-0887

Pierre Montay‐Gruel, Audrey Bouchet, Maud Jaccard, David Patin, Raphaël Serduc, Warren Aim, Kristoffer Petersson, Benoît Petit, Claude Bailat, Jean Bourhis, Elke Bräuer‐Krisch, Marie‐Catherine Vozenin,

Effects of Radiation Exposure

This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.