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Ambulatory oxygen and quality of life in interstitial lung disease

2018; Elsevier BV; Volume: 6; Issue: 10 Linguagem: Inglês

10.1016/s2213-2600(18)30337-0

2213-2619

David B. Page, Victor J. Thannickal,

Pulmonary Hypertension Research and Treatments

Management of fibrotic interstitial lung disease remains challenging because few interventions that improve quality of life are available. Approved drug therapies that reduce the rate of decline in lung function in idiopathic pulmonary fibrosis, the most common and fatal interstitial lung disease, do not improve quality of life. 1 King Jr, TE Bradford WZ Castro-Bernardini S et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014; 370: 2083-2092 Crossref PubMed Scopus (2424) Google Scholar , 2 Richeldi L du Bois RM Raghu G et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014; 370: 2071-2082 Crossref PubMed Scopus (2708) Google Scholar Despite the absence of oxygen desaturation at rest, patients with fibrotic interstitial lung disease typically develop rapid desaturations and dyspnoea during minimal exercise. However, the potential benefits of ambulatory oxygen to counter exertional dyspnoea are unproven and controversial. 3 Bell EC Cox NS Goh N et al. Oxygen therapy for interstitial lung disease: a systematic review. Eur Respir Rev. 2017; 26: 160080 Crossref PubMed Scopus (86) Google Scholar Although acute oxygen therapy in the laboratory setting can improve exercise endurance, 4 Schaeffer MR Ryerson CJ Ramsook AH et al. Effects of hyperoxia on dyspnoea and exercise endurance in fibrotic interstitial lung disease. Eur Respir J. 2017; 49: 1602494 Crossref PubMed Scopus (34) Google Scholar data supporting beneficial effects of ambulatory oxygen in the daily lives of patients with interstitial lung disease have not been reported. Effect of ambulatory oxygen on quality of life for patients with fibrotic lung disease (AmbOx): a prospective, open-label, mixed-method, crossover randomised controlled trialAmbulatory oxygen seemed to be associated with improved HRQOL in patients with interstitial lung disease with isolated exertional hypoxia and could be an effective intervention in this patient group, who have few therapeutic options. However, further studies are needed to confirm this finding. Full-Text PDF