Produção Nacional
Revisado por pares
Telmisartan Modulates the Oral Mucositis Induced by 5-Fluorouracil in Hamsters
2018; Frontiers Media; Volume: 9; Linguagem: Inglês
10.3389/fphys.2018.01204
ISSN1664-042X
AutoresMaisie Mitchele Barbosa Oliveira, Aurigena Antunes de Araújo, Raimundo Fernandes de Araújo Júnior, Gerlane Coelho Bernardo Guerra, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitão, Susana Barbosa Ribeiro, Emanuella de Aragão Tavares, Roseane Carvalho Vasconcelos, Vinícius Barreto Garcia, Caroline Addison Carvalho Xavier de Medeiros,
Tópico(s)Oral and gingival health research
ResumoOral mucositis (OM) is a common adverse effect resulting from cancer therapy. The OM it has implications that may compromise oncologic treatment and decrease the patient's quality of life. The therapeutic options to prevent or treat the symptoms of OM are scarce; there is no effective therapy that improves the symptoms. Based on the need for further research for the treatment of OM, the present study objective was to evaluate the effect of telmisartan (TELM) on the OM induced by 5-fluorouracil (5-FU), using as animal model Golden Syrian hamsters. 5-FU followed by mechanical trauma on day 4 was used to induce OM in hamsters. Euthanasia occurred on the day 10. The experiments were constituted by the groups saline, mechanical trauma, 5-FU, and TELM in three doses (1, 5, or 10 mg/kg). Macroscopic, histopathological, and immunohistochemical analyses as well as immunofluorescence experiments were performed on the oral mucosa of the animals. The samples also were used for analysis enzyme-linked immunosorbent assays and quantitative real-time polymerase chain reactions (qPCR). TELM (5 or 10 mg/kg) was able to reduce the inflammatory ulceration and infiltration in the oral mucosa of the animals, decreasing the levels of the cytokines TNF-α and IL-1β. These treatments was minimize the immunostaining for cyclooxygenase-2, matrix metalloproteinase-9, transforming growth factor-β, and smad 2/3. The nuclear transcription factor kappa B (NFκB) p65 and inducible nitric oxide synthase were reduced in the oral mucosa. Finally, TELM (10 mg/kg) increased the PPARγ gene expression and reduced STAT1 and NFκB p65 gene expression relative to the 5-FU group. Therefore, TELM prevents the OM produced by 5-FU on animal model.
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