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A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial vaginosis

2018; Royal Society of Chemistry; Volume: 54; Issue: 76 Linguagem: Inglês

10.1039/c8cc06300a

1364-548X

Guang‐jian Liu, Beihan Wang, Yuan Zhang, Guo‐wen Xing, Xiao‐Li Yang, Shu Wang,

Molecular Sensors and Ion Detection

We report a turn-on tetravalent sialic acid-coated tetraphenylethene luminogen (TPE4S) with excellent hydrophilicity, good stability, high sensitivity and unique selectivity towards sialidases, and the maximum fluorescence enhancement was ∼40 fold. More importantly, TPE4S was successfully utilized for the screening of sialidase inhibitors and diagnosis of bacterial vaginosis.