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Off-label use of ceftiofur in one-day chicks triggers a short-term increase of ESBL-producing E. coli in the gut

2018; Public Library of Science; Volume: 13; Issue: 9 Linguagem: Inglês

10.1371/journal.pone.0203158

1932-6203

Mauro de Mesquita Souza Saraiva, Alexandre Lemos de Barros Moreira Filho, Oliveiro Caetano de Freitas Neto, Núbia Michelle Vieira da Silva, Patrícia Emília Naves Givisiez, Wondwossen A. Gebreyes, Celso José Bruno de Oliveira,

Antibiotics Pharmacokinetics and Efficacy

This trial was designed to evaluate the off-label use of ceftiofur with Marek's vaccine in one-day-old broiler chicks, a prophylactic treatment that has been done in some commercial hatcheries, on the emergence of extended-spectrum beta-lactamase producing Escherichia coli (ESBL-E. coli). A total of 168 chicks (Cobb500®) were used in a completely randomized design. Birds were assigned to two treatments (Marek's vaccine plus saline vs Marek's vaccine plus ceftiofur) and six repetitions, with 14 animals each. Cloacal swabs were collected from 1 to 14 days post-hatch. The majority (86%; p<0.0001) of the ESBL-producing isolates harboring blaCTX-M and blaSHV genes originated from animals receiving the antimicrobial. None of the isolates were positive for plasmid-mediated AmpC betalactamase genes (blaACC, blaCMY-2, blaDHA, blaFOX, blaMOX and blaMIR). These findings indicate that the off-label use of ceftiofur with Marek's vaccine is associated with the short-term increase in ESBL-producing Escherichia coli in the gut of chicks.