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In vivo generation of human CD 19‐ CAR T cells results in B‐cell depletion and signs of cytokine release syndrome

2018; Springer Nature; Volume: 10; Issue: 11 Linguagem: Inglês

10.15252/emmm.201809158

1757-4684

Anett Pfeiffer, Frederic B. Thalheimer, Sylvia Hartmann, Annika M. Frank, R. Bender, Simon Danisch, Caroline Costa, Winfried S. Wels, Ute Modlich, Renata Stripecke, Els Verhoeyen, Christian J. Buchholz,

T-cell and B-cell Immunology

Chimeric antigen receptor (CAR) T cells brought substantial benefit to patients with B-cell malignancies. Notwithstanding, CAR T-cell manufacturing requires complex procedures impeding the broad supply chain. Here, we provide evidence that human CD19-CAR T cells can be generated directly