Impact of air‐handling system exhaust failure on dissemination pattern of simulant pathogen particles in a clinical biocontainment unit
2018; Wiley; Volume: 29; Issue: 1 Linguagem: Inglês
10.1111/ina.12506
ISSN1600-0668
AutoresJennifer Therkorn, David Drewry, Thomas Pilholski, Kathryn Shaw‐Saliba, Gregory Bova, Lisa L. Maragakis, Brian T. Garibaldi, Lauren Sauer,
Tópico(s)Food Safety and Hygiene
ResumoIndoor AirVolume 29, Issue 1 p. 143-155 ORIGINAL ARTICLE Impact of air-handling system exhaust failure on dissemination pattern of simulant pathogen particles in a clinical biocontainment unit Jennifer Therkorn, Corresponding Author Jennifer Therkorn Jennifer.Therkorn@jhuapl.edu orcid.org/0000-0001-7742-9938 Applied Biological Sciences, Johns Hopkins Applied Physics Laboratory, Laurel, Maryland Correspondence Jennifer Therkorn, Johns Hopkins Applied Physics Laboratory, Laurel, MD. Email: Jennifer.Therkorn@jhuapl.eduSearch for more papers by this authorDavid Drewry III, David Drewry III Applied Biological Sciences, Johns Hopkins Applied Physics Laboratory, Laurel, MarylandSearch for more papers by this authorThomas Pilholski, Thomas Pilholski Applied Biological Sciences, Johns Hopkins Applied Physics Laboratory, Laurel, MarylandSearch for more papers by this authorKathryn Shaw-Saliba, Kathryn Shaw-Saliba Johns Hopkins University School of Medicine, Baltimore, Maryland Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandSearch for more papers by this authorGregory Bova, Gregory Bova Johns Hopkins Health System, Baltimore, MarylandSearch for more papers by this authorLisa L. Maragakis, Lisa L. Maragakis Johns Hopkins University School of Medicine, Baltimore, Maryland Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Johns Hopkins Health System, Baltimore, MarylandSearch for more papers by this authorBrian Garibaldi, Brian Garibaldi Johns Hopkins University School of Medicine, Baltimore, MarylandSearch for more papers by this authorLauren Sauer, Lauren Sauer Johns Hopkins University School of Medicine, Baltimore, Maryland Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandSearch for more papers by this author Jennifer Therkorn, Corresponding Author Jennifer Therkorn Jennifer.Therkorn@jhuapl.edu orcid.org/0000-0001-7742-9938 Applied Biological Sciences, Johns Hopkins Applied Physics Laboratory, Laurel, Maryland Correspondence Jennifer Therkorn, Johns Hopkins Applied Physics Laboratory, Laurel, MD. Email: Jennifer.Therkorn@jhuapl.eduSearch for more papers by this authorDavid Drewry III, David Drewry III Applied Biological Sciences, Johns Hopkins Applied Physics Laboratory, Laurel, MarylandSearch for more papers by this authorThomas Pilholski, Thomas Pilholski Applied Biological Sciences, Johns Hopkins Applied Physics Laboratory, Laurel, MarylandSearch for more papers by this authorKathryn Shaw-Saliba, Kathryn Shaw-Saliba Johns Hopkins University School of Medicine, Baltimore, Maryland Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandSearch for more papers by this authorGregory Bova, Gregory Bova Johns Hopkins Health System, Baltimore, MarylandSearch for more papers by this authorLisa L. Maragakis, Lisa L. Maragakis Johns Hopkins University School of Medicine, Baltimore, Maryland Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland Johns Hopkins Health System, Baltimore, MarylandSearch for more papers by this authorBrian Garibaldi, Brian Garibaldi Johns Hopkins University School of Medicine, Baltimore, MarylandSearch for more papers by this authorLauren Sauer, Lauren Sauer Johns Hopkins University School of Medicine, Baltimore, Maryland Johns Hopkins Bloomberg School of Public Health, Baltimore, MarylandSearch for more papers by this author First published: 07 September 2018 https://doi.org/10.1111/ina.12506Citations: 9Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Biocontainment units (BCUs) are facilities used to care for patients with highly infectious diseases. However, there is limited guidance on BCU protocols and design. This study presents the first investigation of how HVAC (heating, ventilation, air-conditioning) operating conditions influence the dissemination of fluorescent tracer particles released in a BCU. Test conditions included normal HVAC operation and exhaust failure resulting in loss of negative pressure. A suspension of optical brightener powder and water was nebulized to produce fluorescent particles simulating droplet nuclei (0.5-5 μm). Airborne particle number concentrations were monitored by Instantaneous Biological Analyzers and Collectors (FLIR Systems). During normal HVAC operation, fluorescent tracer particles were contained in the isolation room (average concentration = 1 × 104 ± 3 × 103/Lair). Under exhaust failure, the automated HVAC system maximizes airflow into areas adjacent to isolation rooms to attempt to maintain negative pressure differential. However, 6% of the fluorescent particles were transported through cracks around doors/door handles out of the isolation room via airflow alone and not by movement of personnel or doors. Overall, this study provides a systematic method for evaluating capabilities to contain aerosolized particles during various HVAC scenarios. Recommendations are provided to improve situation-specific BCU safety. Citing Literature Volume29, Issue1January 2019Pages 143-155 RelatedInformation
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