Graves’ disease: Introduction, epidemiology, endogenous and environmental pathogenic factors
2018; Elsevier BV; Volume: 79; Issue: 6 Linguagem: Inglês
10.1016/j.ando.2018.09.002
ISSN2213-3941
AutoresJean-Louis Wémeau, Marc Klein, Jean‐Louis Sadoul, Claire Briet, Fritz‐Line Vélayoudom‐Céphise,
Tópico(s)Growth Hormone and Insulin-like Growth Factors
ResumoGraves’ disease is the most frequent cause of hyperthyroidism. Many questions remain about the choice of diagnostic evaluations and treatment strategy according to clinical context (age, gender, pregnancy, etc.) and about the best management of the main extrathyroidal complication that is Graves orbitopathy. The exact pathogenic mechanisms are not fully clear. They associate genetic factors, interactions between endogenous and environmental factors, and immune system dysregulation. Graves’ orbitopathy is one of the consequences of this partial understanding. Iatrogenic Graves’ disease induced by the new targeted therapies are described and could help to better understand the molecular pathways involved in the disease and to develop new therapeutic approaches.
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