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Cu-Catalyzed Decarboxylative Borylation

2018; American Chemical Society; Volume: 8; Issue: 10 Linguagem: Inglês

10.1021/acscatal.8b02928

2155-5435

Jie Wang, Ming Shang, Helena Lundberg, Karla Santos Feu, Scott J. Hecker, Tian Qin, Donna G. Blackmond, Phil S. Baran,

Asymmetric Hydrogenation and Catalysis

A simple method for the conversion of carboxylic acids to boronic esters via redox-active esters (RAEs) is reported using copper catalysis. The scope of this transformation is broad, and compared with the known protocols available, it represents the most inexpensive, rapid, and operationally simple option. In addition to a full exploration of the scope, a kinetic study was performed to elucidate substrate and reagent concentration dependences.