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Evaluation of Lauroyl-Gemcitabine-Loaded Hydrogel Efficacy in Glioblastoma Rat Models

2018; Future Medicine; Volume: 13; Issue: 16 Linguagem: Inglês

10.2217/nnm-2018-0057

1748-6963

Chiara Bastiancich, Laurent Lemaire, John Bianco, Florence Franconi, Fabienne Danhier, Véronique Préat, Guillaume Bastiat, Frédéric Lagarce,

Nanoparticle-Based Drug Delivery

Aim: Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of incurable brain tumors such as glioblastoma (GBM). Recently, we demonstrated the efficacy of lauroyl-gemcitabine lipid nanocapsule hydrogel (GemC12-LNC) in a U-87 MG xenograft orthotopic mouse model. In this study, we developed a reliable and reproducible surgical procedure to resect orthotopic GBM tumors in rats. GemC12-LNC hydrogel integrity was tested after brain administration in rats and its anti-tumor efficacy was tested on a 9L syngeneic orthotopic model. Results: We demonstrated that LNC integrity is maintained at least for one week after local administration of GemC12-LNC. GemC12-LNC was able to delay the formation of recurrences in 9L tumor-bearing resected rats, demonstrating the efficacy of this nanomedicine hydrogel in this preclinical model. Conclusion: Our results confirm that GemC12-LNC, a hydrogel uniquely formed by a nanocarrier and a cytotoxic drug, could be a promising and safe delivery tool for the local treatment of operable GBM tumors.