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2 Angiogenic markers (sflt-1, plgf) in patients with suspected und confirmed placental dysfunction (preeclampsia, IUGR, placental abruption) – continuous values according to biochemical, clinical symptoms and particular perinatal results

2018; Elsevier BV; Volume: 13; Linguagem: Inglês

10.1016/j.preghy.2018.08.148

2210-7797

Sebastian Kwiatkowski, Magdalena Bednarek-Jędrzejek, Joanna Ksel, Piotr Tousty, Ewa Kwiatkowska, Rafał Rzepka, Barbara Michalczyk, Wioletta Mikołajek-Bedner, Aneta Cymbaluk, Andrzej Torbé,

Pregnancy and preeclampsia studies

To assess value of the serum level of soluble Fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF) and sFlt-1/PlGF ratio according to clinical, ultrasound, biochemical symptoms and particular perinatal results in pregnant women with suspected/confirmed placental dysfunction (preeclampsja, IUGR, HELLP, placental abruption). 927 pregnant women between 18 and 41 weeks of pregnancy with suspected/confirmed placental dysfunction. Everyone woman included to cohort had introduced monolithe clinical, biochemical, ultrasound management and sFlt-1, PLGF, sFlt-1/PlGF ratio was assessed. In patients with confirmed placental dysfunction sFlt-1/PlGF ratio was higher independent from clinical symptoms compare to patients who didn’t develop clinical placental dysfunction. Trial occurs statistical correlation angiogenic markers with parameters doppler ultrasound (i.e umbilical artery, uterine artery) traditional biochemical predictors (i.e. uric acid, AST,ALT, LDH, prothrombin time), clinical symptoms (systolic and diastolic pressure) and perinatal results (prematurity, days to delivery, birth weight, pH umbilical blood). Angiogenic markers sFlt-1 i PlGF and sFlt-1/PlGF ratio increase in placental dysfunction independent from clinical presentation. The values angiogenic markers correlate with traditional clinical, ultrasound, biochemical parameters and there are independent predictors perinatal results. sFlt-1/PlGF is helpful in diagnosis and monitoring women with suspected/confirmed placental dysfunction and can be useful in making therapeutic decisions in the future.