Portal de Periódicos da CAPES

SanXoT: a modular and versatile package for the quantitative analysis of high-throughput proteomics experiments

2018; Oxford University Press; Volume: 35; Issue: 9 Linguagem: Inglês

10.1093/bioinformatics/bty815

1367-4811

Marco Trevisán-Herraz, Navratan Bagwan, Fernando Jose Garcia-Marques, José Manuel Rodrı́guez, Inmaculada Jorge, Iakes Ezkurdia, Elena Bonzón‐Kulichenko, Jesús Vázquez,

Metabolomics and Mass Spectrometry Studies

Mass spectrometry-based proteomics has had a formidable development in recent years, increasing the amount of data handled and the complexity of the statistical resources needed. Here we present SanXoT, an open-source, standalone software package for the statistical analysis of high-throughput, quantitative proteomics experiments. SanXoT is based on our previously developed weighted spectrum, peptide and protein statistical model and has been specifically designed to be modular, scalable and user-configurable. SanXoT allows limitless workflows that adapt to most experimental setups, including quantitative protein analysis in multiple experiments, systems biology, quantification of post-translational modifications and comparison and merging of experimental data from technical or biological replicates.Download links for the SanXoT Software Package, source code and documentation are available at https://wikis.cnic.es/proteomica/index.php/SSP.jvazquez@cnic.es or ebonzon@cnic.es.Supplementary information is available at Bioinformatics online.