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RNA modifications modulate gene expression during development

2018; American Association for the Advancement of Science; Volume: 361; Issue: 6409 Linguagem: Inglês

10.1126/science.aau1646

1095-9203

Michaela Frye, Bryan T. Harada, Mikaela Behm, Chuan He,

RNA Research and Splicing

RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example,