Comparative Study of Adjuvants for Allergen-Specific Immunotherapy in a Murine Model
2018; Future Medicine; Volume: 10; Issue: 14 Linguagem: Inglês
10.2217/imt-2018-0072
ISSN1750-7448
AutoresMaría Vázquez de la Torre, M. L. Baeza, Laura Nájera, José Manuel Zubeldia,
Tópico(s)Dermatology and Skin Diseases
ResumoAim: To compare the immunological and clinical changes induced by allergen-specific immunotherapy (AIT) using different adjuvants. Materials & methods: Olea europaea pollen-sensitized mice were treated with olea plus aluminum hydroxide, calcium phosphate, monophosphoryl lipid A (MPL) or immunostimulatory sequences (ISS). Results: Aluminum hydroxide seems to drive initially to a Th2-type response. Bacteria-derived adjuvants (MPL and ISS) skew the immune response toward Th1 and Treg pathways. Specific-IgE production was lower after AIT with MPL and ISS. Moreover, IgG2a production significantly increased in ISS-treated mice. Bacteria-derived adjuvants also improved the Th1 cytokine response due to IFN-γ higher secretion. In addition, they improved bronchial hyper-reactivity and lung inflammation. Conclusion: Bacteria-derived adjuvants may enhance the efficacy of AIT.
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