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The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity

2018; Elsevier BV; Volume: 4; Issue: 11 Linguagem: Inglês

10.1016/j.trecan.2018.09.001

2405-8033

Jan P. Böttcher, Caetano Reis e Sousa,

T-cell and B-cell Immunology

Dendritic cells (DCs) are key orchestrators of immune responses. A specific DC subset, conventional type 1 DCs (cDC1s), has been recently associated with human cancer patient survival and, in preclinical models, is critical for the spontaneous rejection of immunogenic cancers and for the success of T cell-based immunotherapies. The unique role of cDC1 reflects the ability to initiate de novo T cell responses after migrating to tumor-draining lymph nodes, as well as to attract T cells, secrete cytokines, and present tumor antigens within the tumor microenvironment, enhancing local cytotoxic T cell function. Strategies aimed at increasing cDC1 abundance in tumors and enhancing their functionality provide attractive new avenues to boost anti-tumor immunity and overcome resistance to cancer immunotherapies.