Abstract 14403: Neuregulin Attenuates Right Ventricular and Pulmonary Endothelial Dysfunction in an Experimental Model of Pulmonary Hypertension
2012; Lippincott Williams & Wilkins; Linguagem: Inglês
ISSN
1524-4539
AutoresPedro Mendes‐Ferreira, C. Maia-Rocha, Rui M Adão, Rui Cerqueira, Maria José Mendes, André P. Lourenço, Gilles W. De Keulenaer, Adelino Leite‐Moreira, Carmen Brás‐Silva,
Tópico(s)Cardiac Fibrosis and Remodeling
ResumoNeuregulin (NRG)-1 is implicated in the preservation of left ventricular function in pathophysiological conditions. However, the role of NRG-1 in right ventricular (RV) failure is still unknown. We analysed the effects of NRG-1 treatment in an animal model of pulmonary arterial hypertension (PAH) and RV heart failure (HF). Male Wistar rats (180-200g) randomly received monocrotaline (MCT, 60mg/Kg,sc) or vehicle. After 14 days, animals randomly received NRG-1 (40µg/Kg/day,ip) or vehicle, resulting in 4 groups: ctrl (n=10); ctrl+NRG (n=10); MCT (n=10); MCT+NRG (n=10). RV hemodynamics and sample collection for vascular, morphometric, histologic and molecular studies were performed 25-28 days after MCT administration. Only significant results (mean±SEM, p<0.05) are given. MCT group developed PAH, as shown by increased RV maximum pressure (MCT vs ctrl: 63±3 vs 34±3mmHg) and by decreased cardiac output (MCT vs ctrl: 34±4 vs 65±4mL/min) which were both attenuated in the MCT+NRG group (53±3mmHg and 52±2mL/min). An...
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