Produção Nacional
Revisado por pares
Obstructive sleep apnoea as a risk factor for incident metabolic syndrome: a joined Episono and HypnoLaus prospective cohorts study
2018; European Respiratory Society; Volume: 52; Issue: 5 Linguagem: Inglês
10.1183/13993003.01150-2018
ISSN1399-3003
AutoresCamila Hirotsu, José Haba‐Rubio, Sônia Maria Togeiro, Pedro Marques‐Vidal, Luciano F. Drager, Péter Vollenweider, Gérard Waeber, Lia Bittencourt, Sérgio Tufik, Raphaël Heinzer,
Tópico(s)Cardiovascular and Diving-Related Complications
ResumoCross-sectional studies have demonstrated that obstructive sleep apnoea (OSA) and metabolic syndrome (MetS) are often associated, but whether a temporal relationship exists is unknown. We aimed to investigate the effect of OSA on the risk of developing MetS in the general population. A prospective study was conducted combining two population-based samples: Episono (Brazil) and HypnoLaus (Switzerland). MetS was assessed according to unified criteria. Polysomnography (PSG) was performed at baseline and follow-up in Episono, and at baseline in HypnoLaus. OSA was defined according to the apnoea–hypopnoea index as mild (≥5– <15 events h −1 ) and moderate-to-severe (≥15 events·h −1 ). We included 1853 participants (mean± sd age 52±13 years, 56% female) without MetS at baseline. After mean± sd 6±1 years, 318 (17.2%) participants developed MetS. Moderate-to-severe OSA was independently associated with incident MetS (OR 2.58, 95% CI 1.61–4.11) and increased the number of MetS components from baseline to follow-up through mediation of the percentage of time with arterial oxygen saturation <90%. Subset analysis in Episono confirmed that the increase in this parameter between baseline and follow-up PSGs represented a risk factor for incident MetS (OR 1.42, 95% CI 1.04–1.95, for each 10% increase). OSA is independently associated with an increased risk of developing MetS through mediation of nocturnal hypoxaemia in the general population.
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