Produção Nacional
Revisado por pares
Isolation and Identification of the Five Novel Flavonoids from Genipa americana Leaves
2018; Multidisciplinary Digital Publishing Institute; Volume: 23; Issue: 10 Linguagem: Inglês
10.3390/molecules23102521
ISSN1433-1373
AutoresLarissa Silva, Jovelina Samara Ferreira Alves, Emerson da Silva Siqueira, Manoel de Souza Neto, Lucas Silva Abreu, Josean Fechine Tavares, Dayanne Lopes Porto, Leandro De Santis Ferreira, Daniel P. Demarque, Norberto Peporine Lopes, Cícero Flávio Soares Aragão, Silvana Maria Zucolotto,
Tópico(s)Phytochemical compounds biological activities
ResumoGenipa americana is a medicinal plant popularly known as “jenipapo”, which occurs in Brazil and belongs to the Rubiaceae family. It is a species widely distributed in the tropical Central and South America, especially in the Cerrado biome. Their leaves and fruits are used as food and popularly in folk medicine to treat anemias, as an antidiarrheal, and anti-syphilitic. Iridoids are the main secondary metabolites described from G. americana, but few studies have been conducted with their leaves. In this study, the aim was to chemical approach for identify the main compounds present at the extract of G. americana leaves. The powdered leaves were extracted by maceration with EtOH: water (70:30, v/v), following liquid-liquid partition with petroleum ether, chloroform, ethyl acetate and n-butanol. A total of 13 compounds were identified. In addition three flavonoids were isolated from the ethyl acetate fraction: quercetin-3-O-robinoside (GAF 1), kaempferol-3-O-robinoside (GAF 2) and isorhamnetin-3-O-robinoside (GAF 3) and, from n-butanol fraction more two flavonoids were isolated, kaempferol-3-O-robinoside-7-O-rhamnoside (robinin) (GAF 4) and isorhamnetin-3-O-robinoside-7-rhamnoside (GAF 5). Chemical structures of these five flavonoids were elucidated using spectroscopic methods (MS, 1H and 13C-NMR 1D and 2D). These flavonoids glycosides were described for the first time in G. americana.
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