What is pharmacoepidemiology? Definition, methods, interest and clinical applications
2018; Elsevier BV; Volume: 74; Issue: 2 Linguagem: Inglês
10.1016/j.therap.2018.08.001
ISSN1958-5578
AutoresJean‐Louis Montastruc, Justine Bénevent, François Montastruc, Haleh Bagheri, Fabien Despas, Maryse Lapeyre‐Mestre, Agnès Sommet,
Tópico(s)Pharmacovigilance and Adverse Drug Reactions
ResumoClinical evaluation of drugs before approval is based on the experimental design of clinical trial with randomization of drug exposure. Unfortunately, conclusions of clinical trials are necessarily limited to patients included into the trials. It is thus necessary to compare these experimental data coming from clinical trials with the real use of drugs in clinical practice. Pharmacoepidemiology is the study of interactions between drugs and human populations, investigating, in real conditions of life, benefits, risks and use of drugs. Pharmacoepidemiology applies to drugs the methods and/or reasoning of both pharmacology and epidemiology. The development of pharmacoepidemiology should improve the “rational drug use”.
Referência(s)