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Smoking and Risk of Colorectal Cancer Sub-Classified by Tumor-Infiltrating T Cells

2018; Oxford University Press; Volume: 111; Issue: 1 Linguagem: Inglês

10.1093/jnci/djy137

1460-2105

Tsuyoshi Hamada, Jonathan A. Nowak, Yohei Masugi, David A. Drew, Mingyang Song, Yin Cao, Keisuke Kosumi, Kosuke Mima, Tyler S. Twombly, Li Liu, Yan Shi, Annacarolina da Silva, Mancang Gu, Wanwan Li, Katsuhiko Nosho, NaNa Keum, Marios Giannakis, Jeffrey A. Meyerhardt, Kana Wu, Molin Wang, Andrew T. Chan, Edward L. Giovannucci, Charles S. Fuchs, Reiko Nishihara, Xuehong Zhang, Shuji Ogino,

Colorectal Cancer Screening and Detection

Evidence indicates not only carcinogenic effect of cigarette smoking but also its immunosuppressive effect. We hypothesized that the association of smoking with colorectal cancer risk might be stronger for tumors with lower anti-tumor adaptive immune response.