Produção Nacional
Revisado por pares
In vitro and in silico studies of antioxidant activity of 2-thiazolylhydrazone derivatives
2018; Elsevier BV; Volume: 86; Linguagem: Inglês
10.1016/j.jmgm.2018.10.007
ISSN1873-4243
AutoresVinícius Gonçalves Maltarollo, Marina Ferrara de Resende, Thales Kronenberger, Cleudiomar Inácio Lino, Maria Clara Pinheiro Duarte Sampaio, Maíra Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo, Renata Adriana Labanca, Renata Barbosa de Oliveira,
Tópico(s)Synthesis and biological activity
ResumoThe antioxidant potential of a series of thiazolylhydrazone derivatives was investigated using three different methods namely DPPH, ABTS and FRAP assays. In general, the tested compounds showed higher or comparable activity to that of curcumin, used as positive control. Chemometric analyses demonstrated that the presence of hydrazone moiety is required for the activity of this class of compounds. From these results, compound 4 was identified as the most promising molecule and was then selected for further studies. The antiproliferative effect of compound 4 was evaluated, being active in three (T47D, MDA-MB-231 and SKMEL) of the six cancer cell lines tested, with IC50 values ranging from 15.9 to 31.3 μM. Compound 4 exhibited no detectable cytotoxic effect on peripheral blood mononuclear cells (PBMC) when tested at a concentration of 100 μM, demonstrating good selectivity. From these results, it is possible to infer that there is a correlation between antioxidant capacity and anticancer effects.
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