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Antibiotic resistance: a rundown of a global crisis

2018; Dove Medical Press; Volume: Volume 11; Linguagem: Inglês

10.2147/idr.s173867

1178-6973

Bilal Aslam, Wei Wang, Muhammad Arshad, Mohsin Khurshid, Saima Muzammil, Muhammad Hidayat Rasool, Muhammad Atif Nisar, Ruman Farooq Alvi, Muhammad Aamir Aslam, Muhammad Usman Qamar, Muhammad Khalid Farooq Salamat, Zulqarnain Baloch,

Pharmaceutical and Antibiotic Environmental Impacts

Abstract: The advent of multidrug resistance among pathogenic bacteria is imperiling the worth of antibiotics, which have previously transformed medical sciences. The crisis of antimicrobial resistance has been ascribed to the misuse of these agents and due to unavailability of newer drugs attributable to exigent regulatory requirements and reduced financial inducements. Comprehensive efforts are needed to minimize the pace of resistance by studying emergent microorganisms, resistance mechanisms, and antimicrobial agents. Multidisciplinary approaches are required across health care settings as well as environment and agriculture sectors. Progressive alternate approaches including probiotics, antibodies, and vaccines have shown promising results in trials that suggest the role of these alternatives as preventive or adjunct therapies in future. Keywords: antibiotics, multidrug resistance, evolution, alternative therapies