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Multisite study of the relationships between antemortem [ 11 C]PIB‐PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

2018; Wiley; Volume: 15; Issue: 2 Linguagem: Inglês

10.1016/j.jalz.2018.09.001

1552-5279

Renaud La Joie, Nagehan Ayakta, William W. Seeley, Ewa Borys, Adam L. Boxer, Charles DeCarli, Vincent Doré, Lea T. Grinberg, Eric J. Huang, Ji‐Hye Hwang, Miloš D. Ikonomović, Clifford R. Jack, William J. Jagust, Lee‐Way Jin, William E. Klunk, Julia Kofler, Orit H. Lesman‐Segev, Samuel N. Lockhart, Val J. Lowe, Colin L. Masters, Chester A. Mathis, Catriona McLean, Bruce L. Miller, Daniel Mungas, James P. O’Neil, John Olichney, Joseph E. Parisi, Ronald C. Petersen, Howard J. Rosen, Christopher C. Rowe, Salvatore Spina, Prashanthi Vemuri, Victor L. Villemagne, Melissa E. Murray, Gil D. Rabinovici,

Functional Brain Connectivity Studies

We sought to establish the relationships between standard postmortem measures of AD neuropathology and antemortem [11C]PIB-positron emission tomography ([11C]PIB-PET) analyzed with the Centiloid (CL) method, a standardized scale for Aβ-PET quantification.Four centers contributed 179 participants encompassing a broad range of clinical diagnoses, PET data, and autopsy findings.CL values increased with each CERAD neuritic plaque score increment (median -3 CL for no plaques and 92 CL for frequent plaques) and nonlinearly with Thal Aβ phases (increases were detected starting at phase 2) with overlap between scores/phases. PET-pathology associations were comparable across sites and unchanged when restricting the analyses to the 56 patients who died within 2 years of PET. A threshold of 12.2 CL detected CERAD moderate-to-frequent neuritic plaques (area under the curve = 0.910, sensitivity = 89.2%, specificity = 86.4%), whereas 24.4 CL identified intermediate-to-high AD neuropathological changes (area under the curve = 0.894, sensitivity = 84.1%, specificity = 87.9%).Our study demonstrated the robustness of a multisite Centiloid [11C]PIB-PET study and established a range of pathology-based CL thresholds.